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KMID : 0923620100100040126
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Immune Network
2010 Volume.10 No. 4 p.126 ~ p.134
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Expression of Hepatitis B Virus X Protein in Hepatocytes Suppresses CD8+ T Cell Activ
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Lee Mi-Jin
Jin Young-Hee
Kim Kyong-Min
Choi Yang-Kyu
Kim Hyoung-Chin
Park Sun
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Abstract
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Background: CD8+ T cells contribute to the clearance of Hepatitis B virus (HBV) infection and an insufficient CD8+ T cell response may be one of the major factors leading to chronic HBV infection. Since the HBx antigen of HBV can up-regulate cellular expression of several immunomodulatory molecules, we hypothesized that HBx expression in hepatocytes might affect CD8+ T cell activity.
Methods: We analyzed the activation and apoptosis of CD8+ T cells co-cultured with primary hepatocytes rendered capable of expressing HBx by recombinant baculovirus infection.
Results: Expression of HBx in hepatocytes induced low production of interferon-? and apoptosis of CD8+ T cells, with no effect on CD8 T cell proliferation. However, transcriptional levels of H-2K, ICAM-1 and PD-1 ligand did not correlate with HBx expression in hepatocytes.
Conclusion: Our results suggest that HBx may inhibit CD8+ T cell response by regulation of interferon-? production and apoptosis.
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KEYWORD
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Hepadnaviridae, T-lymphocytes, Cytotoxic, Viral proteins, Apoptosis, Interferon-?
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